Principal Scientist, Extrahepatic siRNA delivery (San Diego)

Job Description Summary

The Extrahepatic siRNA Targeting group is looking for a highly motivated and talented cell biologist with strong expertise in cell biology and functional genomics. The ideal candidate will have a deep knowledge of cell surface receptor biology, endocytosis, and recycling to the cell surface. You will be responsible for investigating mechanistic aspects of in vivo siRNA delivery by cell surface receptors and their cognate ligands.

Job Description

The Extrahepatic siRNA Targeting group is seeking a motivated cell biologist skilled in cell biology and functional genomics. The candidate should have extensive knowledge of cell surface receptor biology, endocytosis, and recycling. Responsibilities include investigating in vivo siRNA delivery mechanisms involving cell surface receptors and ligands.

About the Role:

Internal Job Title: Principal Scientist II

Position location: San Diego, CA, onsite

The candidate will focus on receptor biology, endocytosis, and recycling to understand siRNA delivery mechanisms.

Your responsibilities include, but are not limited to:

• Extensive experience in cell surface receptor biology, especially receptor endocytosis and recycling
• Leadership or managerial experience
• Experience with drug discovery is a plus
• Lead research on mechanistic understanding of siRNA delivery via cell surface receptors
• Stay current with assay technology advancements
• Collaborate across teams and with external partners
• Review and interpret technical data accurately
• Present scientific findings
• Maintain safety and quality standards in the lab
• Perform other related duties as needed

Minimum requirements:

• PhD in cell biology or related field, with 5+ years of relevant industry or academic experience
• Knowledge of mammalian receptor biology
• Experience with cell biology techniques like immunofluorescence microscopy, flow cytometry
• Ability to work in cross-functional teams and adapt quickly
• Strong organizational, communication, and time management skills
• Publication and presentation record preferred

Why Novartis : Our purpose is to reimagine medicine to improve and extend people's lives. Join us and be part of this mission. More info:

You'll receive : Benefits and rewards info in the Novartis Life Handbook:

Compensation and Benefits : Salary range $114,100 - $211,900/year, with potential bonuses, stock, and other benefits. Final salary depends on various factors. Details provided upon offer.

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EEO Statement: We are Equal Opportunity Employers. We do not discriminate based on race, color, religion, sex, national origin, age, sexual orientation, gender identity, marital or veteran status, disability, or other protected status.

Accessibility and accommodations : We provide reasonable accommodations for individuals with disabilities. Contact us at or call +1(877)395-2339 with your request and contact info, including job requisition number.