Senior Program Manager (San Francisco)

About Probably Genetic

Probably Genetic is changing the lives of patients living with severe, complex diseases. Our data platform is used by drug developers and patient advocacy groups to develop and launch treatments for these patients. Our technology discovers undiagnosed patients online, analyzes their disease state using machine learning and at-home testing, and enables compliant communication with patients. In doing so, we help patients access diagnoses, clinical trials, and treatments as early as possible.

We are a tight-knit group of hard-working, ambitious problem solvers united by a mission greater than ourselves. We do well by doing right by patients. We are developing some of the most cutting-edge solutions in healthcare, and our roadmap is packed with innovations in bioinformatics, AI, and drug development. We have built a lean, all-star team to help us bring our vision to life, and we want you to be a part of it.

Probably Genetic has raised multiple rounds of funding from Silicon Valley’s best investors, including Threshold, Khosla, and Y Combinator, and offer competitive salaries, comprehensive benefits, and meaningful early stage equity.

About the Role

We are seeking a proactive, strategic, and operationally-minded Senior Program Manager who will be responsible for the execution, delivery, and cross-functional coordination of our genetic disease programs. This role sits at the intersection of our internal teams and client delivery, ensuring programs are well-researched, expertly planned, and flawlessly executed to meet both patient impact and client expectations.

What You'll Do

• Lead Cross-Functional Program Delivery: Drive end-to-end program delivery from research through completion, serving as the central coordinator across ML, growth, business development, and operations teams. Manage complex timelines, dependencies, and cross-functional resources to deliver exceptional outcomes for biotech and pharmaceutical clients.

  • Opportunities for automation: Program offer generation, progress reporting, completion insights, internal communications via Slack/Zapier

  • Opportunities for creative human intervention: Strategic problem-solving for implementation challenges, leading operational decision-making, translating automated insights into actionable strategies

• Build Strategic Client Partnerships: Act as the primary client liaison, facilitating seamless execution and translating complex scientific needs into actionable internal plans. Maintain the highest standards of professionalism while representing company values.

  • Opportunities for automation: Meeting scheduling, note capture with action items, dashboard reporting

  • Opportunities for creative human intervention: Strategic client consultation, nuanced scientific storytelling using data insights, creating compelling assets for client dissemination

• Champion Patient-Centered Scientific Excellence : Leverage deep disease area expertise to inform program strategy and delivery. Collaborate with patient advocacy groups, researchers, and key opinion leaders to amplify patient voices and drive meaningful outcomes.

  • Opportunities for automation: Literature synthesis via NotebookLM, lead identification and outreach, content creation support

  • Opportunities for creative human intervention: Curating high-quality scientific publications, ensuring insights translate into effective ML and growth strategies, building authentic relationships with patient advocacy communities

• Design Scalable Operations & Quality Systems : Design scalable processes that balance automation efficiency with scientific rigor. Develop SOPs, risk mitigation frameworks, and quality control systems that ensure consistent, high-caliber deliverables.

  • Opportunities for automations: SOW template generation, document synthesis, reporting dashboards

  • Opportunities for creative human intervention: Scientific accuracy validation, process optimization based on program learnings, strategic guidance on client-facing analytics and communications

• Drive Business Impact Through Data-Driven Insights : Partner with business development to translate contracts into executable scientific programs. Provide data-driven insights on program outcomes to optimize future offerings and demonstrate ROI to stakeholders. Partner with CEO on key special projects that propel the business towards the next phase of growth.

Who you are

We are looking for a few specific things that will help you succeed in this role:

• Patient-centric mindset with demonstrated ability to manage complex projects and navigate challenging organizational dynamics

• Scientific communication skills that distill complex genetic and medical topics while maintaining strong business intuition with both internal and external stakeholders of all levels

• Data fluency with ability to quickly analyze complex datasets and translate findings into clear, actionable insights for stakeholders

• Patient engagement expertise with authentic ability to connect with individuals facing daily health challenges and symptoms

• Project management mastery including organized approach, clear decision-making capabilities, and appropriate escalation protocols leveraging sound project management fundamentals and advanced program management methodologies

• Relationship building strength to develop and deepen connections with diverse individuals and organizations

• Startup agility with a resourceful, results-driven approach to problem-solving and execution

Some things that are not required, but you will learn on the job:

• Rare disease landscape across the diverse conditions our clients focus on

• Genomics foundations including genetic variants and unique disease characteristics

• Biopharma industry dynamics and unmet needs for drug developers, especially in rare disease research

As with all new hires at Probably Genetic, you will also need to be:

• A good person. We work with some of the most marginalized populations on the planet and empathy is key

• Patient-focused and motivated to have a lasting, positive impact on humanity

• Comfortable in a fast-paced, often ambiguous environment with rapid change

• Action-oriented and excited to build a company from the ground up

The salary range for this role is $112,000-$155,000 annually. Actual compensation offered will depend on several factors including but not limited to: work experience, education, skill level, and/or other business and organizational needs.

What we offer at Probably Genetic:

• An engaging and supportive team all on a mission to improve lives

• Fair and equitable compensation with competitive early-stage equity grants

• Generous Flexible Time off policy, that we actually use

• Parental Leave Benefits (12 weeks for both birthing and non-birthing)

• Hybrid, flexible work with high-trust and autonomy

• A bright, inviting, pet-friendly office in Downtown SF near transit

• A “work from anywhere” policy, up to 4 weeks a year

• Regular team retreats in exciting destinations

• Health Benefits including medical, dental, vision, therapy, FSA, and 401k

• And so much more!

Probably Genetic is committed to fostering a welcoming and inclusive work environment for people of all genders, sexuality, ethnicity, socioeconomic background and life experiences. We urge candidates of all backgrounds to apply. If you require specific accommodations as you interview or consider working with us, please let us know.