Scientific Director, In Vivo & Translational Sciences (Boston)

Employment Type: Full-time

You will be a cross-functional scientific leader working across multiple incubated companies and therapeutic programs, overseeing the design and execution of critical in vivo studies and pharmacology strategies. Your leadership will shape studies from early tool compound proof-of-concept (PoC) through IND-enabling work, including non-human primates (NHP). You will collaborate closely with cross-disciplinary teams, external partners, CROs, and scientists in the incubated companies to enable high-quality, data-driven decisions that advance pipeline assets toward development candidate (DC) nomination and beyond.

Key Responsibilities

• Oversee the design of in vivo studies across species (mouse, NHP, etc.), dosing paradigms (single/multi-dose), and modalities.
• Define performance criteria and key decision points to guide program progression from small animal to large animal models and DC nomination.
• Drive the preclinical path from early PoC to IND-enabling studies, establishing clear milestone gating strategies.
• Lead evaluation and interpretation of PK, PD, and biodistribution across multiple programs and platforms.
• Lead CRO selection and strategic relationship management for NHP studies.
• Provide scientific oversight across portfolio programs, guiding both internal and partner teams.

Preferred Background & Experience

• 15+ years of industry experience in biologics-based preclinical drug development (e.g., antibodies, ADCs).
• Hands-on leadership of in vivo pharmacology studies from mouse PoC through IND-enabling work.
• Deep expertise in small and large animal pharmacology and toxicology, including NHP.
• Proven ability to work with cross-functional stakeholders in a dynamic, fast-paced environment.
• Experience managing external partners and CROs, especially in regulated (GLP) contexts.
• Entrepreneurial, data-driven, and collaborative. Thrives in ambiguity and energized by early-stage innovation.
• Broad therapeutic experience is essential to succeed in this role.

What We Offer

• Shaping multiple therapeutic companies from the ground up
• An intellectually diverse, mission-driven team
• Opportunities for long-term equity participation in our venture portfolio
• Competitive compensation, benefits, and flexible working arrangements

Salary range: $290,000 - $360,000

Foresite Labs is an equal opportunity employer. We thrive on diversity and collaboration.

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